Article

Drug mode of action and resource constraints modulate antimicrobial resistance evolution

2023-08-31

Abstract excerpt

One of the key characteristics of an antibiotic drug is its mode of action: bacteriostatic or bactericidal. The effect of drug mode of action on the evolution of resistance has been surprisingly underinvestigated to date. We present a theoretical model comparing the efficacy of bacteriostatic and bactericidal drugs, and drugs of intermediate type, at preventing the evolutionary rescue of an initially susceptible b...

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Literature Corpus work: eb5c24c7-e49c-5151-831c-0245f83223d2
DOI: 10.1101/2023.08.29.555413

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