Article

Haplotype-aware single-cell multiomics uncovers functional effects of somatic structural variation

2021-11-13

Abstract excerpt

Somatic structural variants (SVs) are widespread in cancer genomes, however, their impact on tumorigenesis and intra-tumour heterogeneity is incompletely understood, since methods to functionally characterize the broad spectrum of SVs arising in cancerous single-cells are lacking. We present a computational method, scNOVA, that couples SV discovery with nucleosome occupancy analysis by haplotype-resolved single-ce...

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Literature Corpus work: 14bb51b2-4d84-5001-bb57-0f6ea97faea0
DOI: 10.1101/2021.11.11.468039

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