Article

Single cell tri-channel-processing reveals structural variation landscapes and complex rearrangement processes

2019-11-21

Abstract excerpt

Structural variation (SV), where rearrangements delete, duplicate, invert or translocate DNA segments, is a major source of somatic cell variation. It can arise in rapid bursts, mediate genetic heterogenity, and dysregulate cancer-related pathways. The challenge to systematically discover SVs in single cells remains unsolved, with copy-neutral and complex variants typically escaping detection. We developed single...

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Literature Corpus work: 883ceacf-c189-50e5-9725-d460accf82cd
DOI: 10.1101/849604

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