Article

Joint analysis of expression and variation at single cell resolution by scVar

2025-10-14

Abstract excerpt

Tumor heterogeneity represents a critical determinant affecting both cancer diagnosis and therapeutic efficacy. Traditional bulk sequencing approaches are limited in their ability to resolve genomic alterations at the resolution of individual cells. In this study, we present scVar, an integrated analytical framework designed for mutation profiling using single-cell transcriptomic data. scVar enables sensitive and...

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Literature Corpus work: bde2b51e-b1cc-5c38-b006-5abd830a6cf1
DOI: 10.1101/2025.10.12.681753

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