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Functional analysis of structural variants in single cells using Strand-seq

24 Nov 2022

Abstract excerpt

Somatic structural variants (SVs) are widespread in cancer, but their impact on disease evolution is understudied due to a lack of methods to directly characterize their functional consequences. We present a computational method, scNOVA, which uses Strand-seq to perform haplotype-aware integration of SV discovery and molecular phenotyping in single cells by using nucleosome occupancy to infer gene expression as a...

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PMID: 36424487
DOI: 10.1038/s41587-022-01551-4

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