Article

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

2020-11-13

Abstract excerpt

The SARS-CoV-2 viral spike (S) protein mediates attachment and entry into host cells and is a major target of vaccine and drug design. Potent SARS-CoV-2 neutralizing antibodies derived from closely related antibody heavy chain genes (IGHV3-53 or 3-66) have been isolated from multiple COVID-19 convalescent individuals. These usually contain minimal somatic mutations and bind the S receptor-binding domain (RBD) to i...

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Literature Corpus work: 14b200b3-e0f2-5f68-a299-26e7ef04e7a4
DOI: 10.1101/2020.11.13.381533

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