Article

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

2021-01-20

Abstract excerpt

<h4>Summary</h4> Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2. We describe a panel of human mAbs binding to diverse epitopes on the N-terminal domain (NTD) of S protein from SARS-CoV-2 convalescent donors and found a minority of these possessed neutrali...

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Literature Corpus work: bcad8ce9-0032-5084-848d-d15c9539e8f0
DOI: 10.1101/2021.01.19.427324

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