Back to search

Article

Elucidating the Humoral Immune Response to SARS-CoV-2: Isolation and Characterization of Monoclonal Antibodies from Convalescent COVID-19 Patients

2025-08-03

Abstract excerpt

The COVID-19 pandemic has underscored the importance of understanding the intricate mechanisms of the humoral immune response to SARS-CoV-2. This study aimed to elucidate the diversity and specificity of antibodies generated from convalescent COVID-19 patients by isolating and characterizing monoclonal antibodies (mAbs) targeting the SARS-CoV-2 spike protein. Employing cutting-edge technologies, including single-c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a98d576b-8124-5e30-963a-307e7d301e46
DOI
10.1101/2025.08.01.25332666
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Elucidating the Humoral Immune Response to SARS-CoV-2: Isolation and Characterization of Monoclonal Antibodies from Convalescent COVID-19 PatientsDOI 10.1101/2025.08.01.25332666
Preclinical Efficacy of IMM-BCP-01, a Highly Active Patient-Derived Anti-SARS-CoV-2 Antibody CocktailSemantic proximity
Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modalitySemantic proximity
Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2Semantic proximity
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasmaSemantic proximity
Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent DonorsSemantic proximity
Neutralizing antibodies targeting SARS-CoV-2 spike proteinSemantic proximity
Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike proteinSemantic proximity
Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2Semantic proximity
Profiling B cell immune responses to identify neutralizing antibodies from convalescent COVID-19 patientsSemantic proximity
Monoclonal Antibodies from COVID-19 Convalescent Patients Target Cryptic Epitopes for Universal SARS-CoV-2 NeutralizationSemantic proximity
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617Semantic proximity
Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognitionSemantic proximity
Select a neighboring publication to make it the new centre.