Article
Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2.
Cell reports - 11 May 2021
Zhou Xiaojuan, Ma Fengge, Xie Jun, Yuan Meng, Li Yunqiao, Shaabani Namir, Zhao Fangzhu, Huang Deli, Wu Nicholas C, Lee Chang-Chun D, Liu Hejun, Li Jiali, Chen Zhonghui, Hong Yazhen, Liu Wen-Hsien, Xiao Nengming, Burton Dennis R, Tu Haijian, Li Hang, Chen Xin, Teijaro John R, Wilson Ian A, Xiao Changchun, Huang Zhe
Abstract excerpt
It is unclear whether individuals with enormous diversity in B cell receptor repertoires are consistently able to mount effective antibody responses against SARS-CoV-2. We analyzed antibody responses in a cohort of 55 convalescent patients and isolated 54 potent neutralizing monoclonal antibodies (mAbs). While most of the mAbs target the angiotensin-converting enzyme 2 (ACE2) binding surface on the receptor...
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