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Article

Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Sept 2003

McCracken Ardythe A, Brodsky Jeffrey L

Abstract excerpt

ER-associated degradation (ERAD) is a component of the protein quality control system, ensuring that aberrant polypeptides cannot transit through the secretory pathway. This is accomplished by a complex sequence of events in which unwanted proteins are selected in the ER and exported to the cytosol for degradation by the proteasome. Given that protein quality control can be essential for cell survival, it is not...

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Identifiers

PMID: 12938176
DOI: 10.1002/bies.10320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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