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Article

Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.

International journal of molecular sciences - 26 Aug 2020

Eura Yuka, Miyata Toshiyuki, Kokame Koichi

Abstract excerpt

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is a quality control system that induces the degradation of ER terminally misfolded proteins. The ERAD system consists of complexes of multiple ER membrane-associated and luminal proteins that function cooperatively. We aimed to reveal the role of Derlin-3 in the ERAD system using the liver, pancreas, and kidney obtained from different mouse...

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Identifiers

PMID: 32858914
DOI: 10.3390/ijms21176146
PMCID: PMC7504720

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