Article

Mapping early patterning events in human neural development using an <i>in-vitro</i> microfluidic stem cell model

2025-05-26

Abstract excerpt

Stem cell models can provide insights into human brain development at embryonic stages which are normally inaccessible. We previously developed the Microfluidic Stem Cell Regionalisation (MiSTR) model, which recapitulates the rostro-caudal patterning of human neural tube through a WNT activation (WNTa) gradient. Through temporal single cell transcriptomics of rostro-caudal and dorso-ventral gradient-patterned MiST...

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Literature Corpus work: 149721af-227f-5277-a6a9-b7db43366f2f
DOI: 10.1101/2025.05.23.655442

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