Article
Analysis pipelines for cancer genome sequencing in mice.
Nature protocols - 1 Feb 2020
Lange Sebastian, Engleitner Thomas, Mueller Sebastian, Maresch Roman, Zwiebel Maximilian, González-Silva Laura, Schneider Günter, Banerjee Ruby, Yang Fengtang, Vassiliou George S, Friedrich Mathias J, Saur Dieter, Varela Ignacio, Rad Roland
Abstract excerpt
Mouse models of human cancer have transformed our ability to link genetics, molecular mechanisms and phenotypes. Both reverse and forward genetics in mice are currently gaining momentum through advances in next-generation sequencing (NGS). Methodologies to analyze sequencing data were, however, developed for humans and hence do not account for species-specific differences in genome structures and experimental...
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