Article

Reconstructing protein interactions at enhancer-promoter regions in prostate cancer

2022-11-21

Abstract excerpt

<title>Abstract</title> <p>DNA-binding proteins (DBPs) and in particular transcription factors interact with enhancers and their target genes through enhancer-promoter (E-P) interactions. Technological advancements such as chromosome conformation capture allow to identify E-P interactions, but the protein networks involved have not yet been characterized. Most importantly, the role of nuclear protein networks in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 146ad8cb-cd88-53ee-aa96-b88183d301ea
DOI: 10.21203/rs.3.rs-2252897/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reconstructing protein interactions at enhancer-promoter regions in prostate cancerDOI 10.21203/rs.3.rs-2252897/v1Read

The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancerSemantic proximity Read

Decoding 3D chromatin architecture reveals distinct enhancer classes underlying hierarchical gene regulation in prostate cancerSemantic proximity Read

Gene regulatory mechanisms underpinning prostate cancer susceptibility.Semantic proximity Read

Comprehensive functional annotation of 77 prostate cancer risk loci.Semantic proximity Read

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.Semantic proximity Read

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.Semantic proximity Read

Intra- and inter-chromosomal chromatin interactions mediate genetic effects on regulatory networksSemantic proximity Read

A proteocistromic atlas of 216 human disease-relevant transcription factorsSemantic proximity Read

PEhub resolves the hierarchical regulatory architecture of multi-way enhancer hubs in the human brainSemantic proximity Read

Promoter-Enhancer Interactions Identified from Hi-C Data using Probabilistic Models and Hierarchical Topological DomainsSemantic proximity Read

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations.Semantic proximity Read

Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.Semantic proximity Read