Article

The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer

2022-10-21

Abstract excerpt

Here we introduce Promoter-ENhancer-GUided Interaction Networks (PENGUIN), a method to uncover protein-protein interaction (PPI) networks at enhancer-promoter contacts. By integrating H3K27ac-HiChIP data and tissue-specific PPI information, PENGUIN enables cluster enhancers-promoter PPI networks (EPINs) and pinpoint actionable factors. Validating PENGUIN in cancer (LNCaP) and benign (LHSAR) prostate cell lines, we...

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Literature Corpus work: ad3f9956-d238-56f0-aa33-eeb6af0f26a2
DOI: 10.1101/2022.10.20.512998

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