Article

Learning to quantify uncertainty in off-target activity for CRISPR guide RNAs

2023-06-02

Abstract excerpt

CRISPR-based genome editing technologies have revolutionised the field of molecular biology, offering unprecedented opportunities for precise genetic manipulation. However, off-target effects remain a significant challenge, potentially leading to unintended consequences and limiting the applicability of CRISPR-based genome editing technologies in clinical settings. Current literature predominantly focuses on point...

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Literature Corpus work: 17fad318-3c91-5e5b-9950-db4959e22a9b
DOI: 10.1101/2023.06.02.543468

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