Article

ACE2 is the critical <i>in vivo</i> receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

2021-08-09

Abstract excerpt

<h4>Summary</h4> Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16 , a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modelling revealed how Spike mutations of maVie16 enhanced interaction with murine ACE2. MaVie16 induced profound pathology in BALB/c and C57BL/6 mice...

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Literature Corpus work: 13ece3c2-68b7-5d72-a43f-d872723b89bc
DOI: 10.1101/2021.08.09.455606

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