Article

Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression

2022-02-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> How well mouse models recapitulate the transcriptional profiles seen in humans remains debatable, with both conservation and diversity identified in various settings. The K18-hACE2 mouse model has been widely used for evaluation of new interventions for COVID-19. <h4>METHOD</h4> Herein we use RNA-Seq data and bioinformatics approaches to compare the transcriptional response...

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Literature Corpus work: bf5bfd4f-4ea7-5b93-9910-f58d73810b65
DOI: 10.1101/2022.02.24.481866

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