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ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions

2021-02-10

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 uses the human ACE2 (hACE2) receptor for cell attachment and entry, with mouse ACE2 (mACE2) unable to support infection. Herein we describe an ACE2-lentivirus system and illustrate its utility for in vitro and in vivo SARS-CoV-2 infection models. Transduction of non-permissive cell lines with hACE2 imparted replication competence, and transduction with mACE2 containing N30D, N31K, F...

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Identifiers and source

Literature Corpus work
80201de4-0e20-58f4-aa2f-0234affc905d
DOI
10.1101/2021.02.09.430547
Open publication

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ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactionsDOI 10.1101/2021.02.09.430547
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