Article

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function

2020-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) emerged in late 2019 and has spread worldwide resulting in the Coronavirus Disease 2019 (COVID-19) pandemic. Although animal models have been evaluated for SARS-CoV-2 infection, none have recapitulated the severe lung disease phenotypes seen in hospitalized human cases. Here, we evaluate heterozygous transgenic mice expressing the hum...

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Literature Corpus work: 8fb1f8b8-0a63-5824-98c7-1ab777fca3a7
DOI: 10.1101/2020.07.09.196188

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