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Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression

26 Sept 2022

Abstract excerpt

How well mouse models recapitulate the transcriptional profiles seen in humans remains debatable, with both conservation and diversity identified in various settings. Herein we use RNA-Seq data and bioinformatics approaches to analyze the transcriptional responses in SARS-CoV-2 infected lungs, comparing 4 human studies with the widely used K18-hACE2 mouse model, a model where hACE2 is expressed from the mouse...

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PMID: 36155667
DOI: 10.1371/journal.ppat.1010867

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