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Unraveling schizophrenia's genetic complexity through advanced causal inference and chromatin 3D conformation.

Schizophrenia research - 1 Aug 2024

Liu Liangjie, Ren Decheng, Li Keyi, Ji Lei, Feng Mofan, Li Zhuoheng, Meng Luming, He Guang, Shi Yi

Abstract excerpt

Schizophrenia is a polygenic complex disease with a heritability as high as 80 %, yet the mechanism of polygenic interaction in its pathogenesis remains unclear. Studying the interaction and regulation of schizophrenia susceptibility genes is crucial for unraveling the pathogenesis of schizophrenia and developing antipsychotic drugs. Therefore, we developed a bioinformatics method named GRACI (Gene Regulation...

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PMID: 38996525
DOI: 10.1016/j.schres.2024.07.005

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