Back to search

Article

SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial Carcinoma

2026-08-06

Abstract excerpt

<h4>Purpose</h4> SWI/SNF (BAF) chromatin remodeling complex alterations are common in urothelial carcinoma, yet no biomarker-directed therapeutic strategies have been established for this population. We investigated whether BAF alterations delineate a biologically distinct, therapeutically actionable urothelial carcinoma subtype. <h4>Experimental Design</h4> We performed integrative genomic and transcriptomic an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
89eb6603-ca49-5bd6-9181-f5305e7c683c
DOI
10.64898/2026.08.05.743022
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial CarcinomaDOI 10.64898/2026.08.05.743022
SWI/SNF-associated molecular subtypes reshape tumor microenvironmental features and inform precision therapeutic strategies in bladder cancer.Semantic proximity
Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapySemantic proximity
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiationSemantic proximity
Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomasSemantic proximity
Delineating SWI/SNF gene and subtype expression in cancer.Semantic proximity
Pan-urologic cancer genomic subtypes that transcend tissue of origin.Semantic proximity
ARID1A-deficiency in urothelial bladder cancer: No predictive biomarker for EZH2-inhibitor treatment response?Semantic proximity
Urothelial-lineage master transcription factor hub proteomics shows mechanisms impeding urothelial cancer cell differentiationSemantic proximity
Clinical and Molecular Characterization of Clear Cell Adenocarcinoma of the Urinary Tract: A Multi-Institutional Study.Semantic proximity
Integrated Genomic and Single-Cell Analysis Reveals Heterogeneity, Prognosis, and Treatment Vulnerability in Urothelial Carcinoma.Semantic proximity
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma.Semantic proximity
Spatial remodeling of the urothelial carcinoma tumor microenvironment shapes response to neoadjuvant atezolizumabSemantic proximity
Select a neighboring publication to make it the new centre.