Article

Distinct clonal dynamics and interactions within the microenvironment near tumor stroma interfaces in rare histologic variants of bladder cancer

2026-03-24

Abstract excerpt

Rare histologic variants of bladder carcinoma, such as squamous cell and neuroendocrine carcinoma, generally have a worse prognosis compared to pure urothelial carcinoma (PUC), but the underlying molecular determinants are not well understood. We developed a novel computational genomics framework to characterize the dynamics of tumor-stroma-immune interactions at tumor borders and interiors from spatial transcript...

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Literature Corpus work: b3500e69-a5ef-5812-917e-68bc3b1cbd5d
DOI: 10.64898/2026.03.21.713423

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