Article

A conserved 8-gene epithelial barrier signature spatially quantifies immune exclusion across cancers and predicts immunotherapy outcome independent of HPV status

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>Background Tumor epithelial barriers physically impede immune cell infiltration, causing immune exclusion and resistance to immune checkpoint inhibitors (ICIs). However, a simple, spatially quantifiable biomarker of epithelial barrier strength is lacking. In head and neck squamous cell carcinoma (HNSCC), HPV status is used as a surrogate for ICI response, but its association with true...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc364a23-d235-5fa3-a510-6ce642b20464
DOI: 10.21203/rs.3.rs-9472940/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A conserved 8-gene epithelial barrier signature spatially quantifies immune exclusion across cancers and predicts immunotherapy outcome independent of HPV statusDOI 10.21203/rs.3.rs-9472940/v1Read

Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell CancerSemantic proximity Read

PSMB5-centered immunotherapy resistance signature predicts prognosis and drives CD8+ T cell exclusion in lung adenocarcinomaSemantic proximity Read

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor MicroenvironmentSemantic proximity Read

Unraveling tumour microenvironment heterogeneity in nasopharyngeal carcinoma identifies biologically distinct immune subtypes predicting prognosis and immunotherapy responsesSemantic proximity Read

Immune and non-immune cell fencing of tumor cells is a widespread and functionally relevant spatial pattern in solid cancersSemantic proximity Read

Integrative Spatial Analysis of H&E and IHC Images Identifies Prognostic Immune Subtypes Correlated with Progression-Free Survival in Human Papillomavirus (HPV)-Related Oropharyngeal Squamous Cell CarcinomaSemantic proximity Read

Multi-omics characterization of cellular state diversity and bidirectional tumor-stroma/immune interactions in cervical squamous cell carcinomaSemantic proximity Read

Spatial tumor immune microenvironment phenotypes in ovarian cancerSemantic proximity Read

Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinomaSemantic proximity Read

Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysisSemantic proximity Read

Integrated single-cell and spatial analysis identifies context-dependent myeloid-T cell interactions in head and neck cancer immune checkpoint blockade responseSemantic proximity Read