Combined Molecular Subclass and Immune Phenotype Correlate to Atezolizumab Plus Radiation Therapy Response in Invasive Bladder Cancer: BPT-ART Phase 2 Study.

doi:10.1016/j.ijrobp.2024.12.019

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Article

Combined Molecular Subclass and Immune Phenotype Correlate to Atezolizumab Plus Radiation Therapy Response in Invasive Bladder Cancer: BPT-ART Phase 2 Study.

International journal of radiation oncology, biology, physics - 1 May 2025

Nagumo Yoshiyuki, Hattori Kyosuke, Kimura Tomokazu, Sekino Yuta, Naiki Taku, Kobayashi Yasuyuki, Matsumoto Takashi, Osawa Takahiro, Kita Yuki, Takemura Masae, Mathis Bryan J, Suzuki Susumu, Tsuzuki Toyonori, Ishikawa Hitoshi, Nishiyama Hiroyuki

Abstract excerpt

PURPOSE: Bladder preservation therapy in combination with atezolizumab and radiation therapy trial, which was a multicenter, open-label, single-arm phase 2 study, showed a promisingly high interim clinical complete response (cCR) rate of 84.4% (38/45). In the present study, we aimed to identify potential tissue biomarkers for achieving cCR using bladder preservation therapy in combination with atezolizumab and...

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PMID: 39755215
DOI: 10.1016/j.ijrobp.2024.12.019

Genes

CDK12
FGFR3
GNAS
NOTCH2

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