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Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

2023-11-17

Abstract excerpt

<h4>Background</h4> Immunotherapy (IO) has improved survival for patients with advanced clear cell renal cell carcinoma (ccRCC), but resistance to therapy develops in most patients. We use cellular-resolution spatial transcriptomics in patients with IO naïve and IO exposed primary ccRCC tumors to better understand IO resistance. Spatial molecular imaging (SMI) was obtained for tumor and adjacent stroma samples. S...

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Literature Corpus work
a1203392-d935-53e8-abb7-0e2b57be04c7
DOI
10.1101/2023.11.16.567457
Open publication

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Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironmentDOI 10.1101/2023.11.16.567457
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