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Spatial Transcriptomic Profiling Uncovers Tumor Heterogeneity and Microenvironmental Features Associated with Lymph Node Metastasis in Invasive Lobular Carcinoma

2026-05-06

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<title>Abstract</title> <p> Background Invasive lobular carcinoma (ILC) is a clinically challenging, largely estrogen receptor‑positive subtype characterized by dis-cohesive, single‑file invasion and frequent lymph‑node involvement. However, the spatial organization of ILC tumor ecosystems and the molecular features associated with nodal dissemination remain insufficiently defined. Methods We profiled a primar...

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Literature Corpus work
17dd9ec2-cadd-5fb8-8792-d4dcce98b29e
DOI
10.21203/rs.3.rs-9227532/v1
Open publication

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Spatial Transcriptomic Profiling Uncovers Tumor Heterogeneity and Microenvironmental Features Associated with Lymph Node Metastasis in Invasive Lobular CarcinomaDOI 10.21203/rs.3.rs-9227532/v1
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