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Roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2011

Ishikawa Katsuyuki, Ohsumi Tatsuya, Tada Shusuke, Natsume Ryo, Kundu Lena Rani, Nozaki Naohito, Senda Toshiya, Enomoto Takemi, Horikoshi Masami, Seki Masayuki

Abstract excerpt

The nucleosome, which is composed of DNA wrapped around a histone octamer, is a fundamental unit of chromatin and is duplicated during the eukaryotic DNA replication process. The evolutionarily conserved histone chaperone cell cycle gene 1 (CCG1) interacting factor A/anti-silencing function 1 (CIA/Asf1) is involved in histone transfer and nucleosome reassembly during DNA replication. CIA/Asf1 has been reported to...

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PMID: 21895891
DOI: 10.1111/j.1365-2443.2011.01549.x

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