Article

Cancer-associated synonymous mutations reveal stress signal-dependent mRNA folding that selectively modulates protein function

2026-01-28

Abstract excerpt

Recent technical advances have facilitated studies on changes in mRNA structures in response to signaling pathways. However, if mRNA structures can affect the function of the encoded protein remains poorly understood. In-cell RNA structural probing (SHAPE-MaP) demonstrates how two cancer-associated synonymous mutations (CASMs) at proline codon 34 (c.102 C>A and c.102 C>G) prevent DNA damage-induced TP53 mRNA fold...

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Literature Corpus work: 138480d9-6db3-5851-b929-c3a61b47950b
DOI: 10.64898/2026.01.26.701754

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