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Article

Shaping the regulation of the p53 mRNA tumour suppressor: the co-evolution of genetic signatures

13 Sept 2019

Abstract excerpt

Structured RNA regulatory motifs exist from the prebiotic stages of the RNA world to the more complex eukaryotic systems. In cases where a functional RNA structure is within the coding sequence a selective pressure drives a parallel co-evolution of the RNA structure and the encoded peptide domain. The p53-MDM2 axis, describing the interactions between the p53 tumor suppressor and the MDM2 E3 ubiquitin ligase,...

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PMID: 31519161
DOI: 10.1186/s12885-019-6118-y

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