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Article

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47

26 Jul 2025

Abstract excerpt

BACKGROUND: Synonymous mutations (SMs) change the mRNA nucleotide sequences without altering the corresponding amino acid sequence and are usually overlooked due to their perceived lack of influence on protein function. However, emerging reports suggest that SMs play a significant role in disease development and progression. METHODS: Whole exome sequencing, RNA-sequencing, and droplet digital PCR were performed...

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PMID: 40715694
DOI: 10.1038/s41416-025-03127-w

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