Article
Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3' untranslated region mutations.
Cell reports - 29 Aug 2023
Schuster Samantha L, Arora Sonali, Wladyka Cynthia L, Itagi Pushpa, Corey Lukas, Young Dave, Stackhouse Bethany L, Kollath Lori, Wu Qian V, Corey Eva, True Lawrence D, Ha Gavin, Paddison Patrick J, Hsieh Andrew C
Abstract excerpt
3' untranslated region (3' UTR) somatic mutations represent a largely unexplored avenue of alternative oncogenic gene dysregulation. To determine the significance of 3' UTR mutations in disease, we identify 3' UTR somatic variants across 185 advanced prostate tumors, discovering 14,497 single-nucleotide mutations enriched in oncogenic pathways and 3' UTR regulatory elements. By developing two complementary...
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