Article

Mutant p53 binds RNA to drive mitochondrial dysfunction

2025-11-13

Abstract excerpt

Tumor suppressor protein 53 (p53) is a transcription factor that is deregulated in 50% of cancers. Often termed the guardian of the genome, p53 is responsible for maintenance of genomic stability, cell cycle arrest, DNA repair, senescence, and apoptosis. In cancer cells, deregulation of p53 often occurs through mutations in the DNA binding domain which lead to a loss of the transcriptional activity. While 100’s of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6da54a92-bc24-5bee-be7f-de1a8af8c73f
DOI: 10.1101/2025.11.12.688127

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 binds RNA to drive mitochondrial dysfunctionDOI 10.1101/2025.11.12.688127Read

Structural biology of the tumor suppressor p53 and cancer-associated mutants.Semantic proximity Read

Structure-function-rescue: the diverse nature of common p53 cancer mutants.Semantic proximity Read

Drug discovery and mutant p53.Semantic proximity Read

High throughput evaluation of genetic variants with prime editing sensor librariesSemantic proximity Read

More targets, more pathways and more clues for mutant p53Semantic proximity Read

In silico analysis of p53 using the p53 knowledgebase: mutations, polymorphisms, microRNAs and pathways.Semantic proximity Read

High-throughput evaluation of genetic variants with prime editing sensor libraries.Semantic proximity Read

Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4Semantic proximity Read

Cancer-associated synonymous mutations reveal stress signal-dependent mRNA folding that selectively modulates protein functionSemantic proximity Read

Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysisSemantic proximity Read

Gain of function of mutant p53: R282W on the peak?Semantic proximity Read

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47Semantic proximity Read