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Article

Cancer-associated synonymous mutations reveal stress signal-dependent mRNA folding that selectively modulates protein function.

RNA (New York, N.Y.) - 16 Jun 2026

Vadivel Gnanasundram Sivakumar, Wang Lixiao, Chen Sa, Bonczek Ondrej, Vojtesek Borivoj, Fahraeus Robin

Abstract excerpt

Recent technical advances have facilitated studies on changes in mRNA structures in response to signaling pathways. However, whether mRNA structures can affect the function of the encoded protein remains poorly understood. In-cell RNA structural probing (SHAPE-MaP) demonstrates how two cancer-associated synonymous mutations (CASMs) at proline codon 34 (c.102 C > A and c.102 C > G) prevent DNA damage-induced TP53...

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Topics

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Share to Cell Line, Tumor
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasms

Share to Promoter Regions, Genetic

Share to RNA Folding

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41997718
DOI: 10.1261/rna.080976.126

Genes

CDKN1A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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