Article

Pan-cancer single-cell analysis identifies a FOXF1/FOXF2-associated transitional CAF-like fibroblast state

2026-07-10

Abstract excerpt

Fibroblast heterogeneity shapes tumor progression, yet the transitional states linking normal-associated fibroblasts to cancer-associated fibroblasts (CAFs) remain poorly defined. Here, we integrated single-cell transcriptomic profiles of more than 90,000 stromal cells from 281 samples across nine cancer types to construct a pan-cancer atlas of fibroblast diversity. We identified a distinct CAF-like population pos...

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Literature Corpus work: 136afae2-9922-5d9a-901c-1a9c84952a82
DOI: 10.64898/2026.07.09.737397

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