Article

A Cancer-Associated Fibroblast Classification Framework for Single-Cell Data

2022-12-16

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are a diverse cell population within the tumour microenvironment, where they have critical effects on tumour evolution and patient prognosis. To define CAF phenotypes, we analysed a single-cell RNA sequencing (scRNA-seq) dataset of over 16,000 stromal cells from tumours of 14 breast cancer patients, based on which we defined and functionally annotated nine CAF phenotypes and on...

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Literature Corpus work: d72097c0-c599-56ae-9e1c-a8ebb4a785cc
DOI: 10.1101/2022.12.14.520398

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