Classifying cancer-associated fibroblasts-The good, the bad, and the target.

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell technologies such as single-cell RNA sequencing. There is no general classification system for CAFs, hampering their study and therapeutic targeting. We propose a simple CAF classification system based on single-cell...

Topics

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• Cancer-Associated Fibroblasts
• Neoplasms
• Phenotype
• Single-Cell Analysis
• Tumor Microenvironment