Article
Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.
Cancer cell - 13 Jul 2026
Liu Yunhe, Chen Xiongfeng, Dai Yibo, Jia Yiyue, Kieffer Yann, Xie Luyu, Zhou Zhuan, Tyler Lauren, Kim Alex C, Biffi Giulia, Krishnamurty Akshay T, Mechta-Grigoriou Fatima, Scherz-Shouval Ruth, Sherman Mara H, Turley Shannon J, Wang Linghua, Huang Huocong
Abstract excerpt
Cancer-associated fibroblasts (CAFs) form a dynamic ecosystem that critically influences tumor progression and therapeutic response. Although recent advances in single-cell and spatial omics have uncovered profound stromal diversity, interpreting the mechanistic relevance of this complexity remains a challenge. Here, we propose a more unifying conceptual framework to bridge high-dimensional data with experimental...
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