Article

Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases

2025-02-07

Abstract excerpt

Tumor necrosis factor-alpha (TNFα) is a key pro-inflammatory cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, and neurodegenerative disorders such as Alzheimer’s Disease. Effective inhibition of TNFα is essential for mitigating disease progression and improving patient outcomes. In this study, we present the develo...

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Literature Corpus work: 1268f1aa-92ea-5d3c-b03f-0adc3613acfd
DOI: 10.1101/2025.02.07.637018

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