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Article

Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library.

Journal of molecular biology - 23 Feb 2007

Liang Wei-Ching, Dennis Mark S, Stawicki Scott, Chanthery Yvan, Pan Qi, Chen Yongmei, Eigenbrot Charles, Yin JianPing, Koch Alexander W, Wu Xiumin, Ferrara Napoleone, Bagri Anil, Tessier-Lavigne Marc, Watts Ryan J, Wu Yan

Abstract excerpt

Non-immune (naïve) antibody phage libraries have become an important source of human antibodies. The synthetic phage antibody library described here utilizes a single human framework with a template containing human consensus complementarity-determining regions (CDRs). Diversity of the libraries was introduced at select CDR positions using tailored degenerate and trinucleotide codons that mimic natural human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17196977
DOI: 10.1016/j.jmb.2006.11.021

Genes

NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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