Article

GABAergic Circuit Activation Induces a Therapeutically Responsive State for anti-PD-L1 Immunotherapy in Glioblastoma

2026-08-27

Abstract excerpt

Glioblastoma (GBM) disrupts cortical excitatory-inhibitory balance and establishes an immunosuppressive microenvironment that limits therapeutic efficacy. Whether restoring inhibitory signaling can restrain glioma progression and improve responsiveness to immune checkpoint blockade remains unknown. Peritumoral parvalbumin-positive (PV + ) interneurons were bidirectionally manipulated by chemogenetics in orthotopi...

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Literature Corpus work: 1353433b-d0d5-5d0b-93e1-99b41e76ee11
DOI: 10.64898/2026.08.26.747200

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