Article

Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis

2025-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GB) is the most common and aggressive adult brain tumor. Recent evidence shows that GB cells form glutamatergic synapses with neurons, promoting tumor growth and invasion, yet the gene regulatory networks (GRNs) underlying this interaction remain underexplored. GRNs coordinate gene expression through interactions among transcription factors (TFs), enhancers, and promoters, and are...

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Literature Corpus work: 6426e88b-c293-5b1a-bb64-0c4eac8ee284
DOI: 10.1101/2025.04.30.651564

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