Article

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43

2023-12-27

Abstract excerpt

TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as “TDP-43 proteinopathies”. Aggregates of TDP-43 are present in the brains and spinal cords of >97% of amyotrophic lateral sclerosis (ALS), and in brains of ∼50% of frontotemporal dementia (FTD) patients. While mutations in the TDP-43 gene ( TARDBP ) are usually associated with ALS, many clinical reports have linked these...

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Literature Corpus work: 6cf046ca-37d9-58bd-beda-93b313fc85f1
DOI: 10.1101/2023.12.27.573393

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