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Article

Neuromuscular junction abnormalities in a zebrafish loss-of-function model of TDP-43

21 Nov 2018

Abstract excerpt

Almost 90% of amyotrophic lateral sclerosis (ALS) cases are characterized by the presence of aggregates of insoluble, misfolded cytoplasmic TAR DNA binding protein of 43 kDa (TDP-43). Distal axonopathy with impaired neuromuscular junctions (NMJs) before motor neuron degeneration or clinical onset of symptoms has been hypothesized as an early pathology in ALS. However, synaptic defects at the NMJ caused by TDP-43...

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PMID: 30461368
DOI: 10.1152/jn.00265.2018

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