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Article

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

2021-12-14

Abstract excerpt

<h4>SUMMARY/ABSTRACT</h4> Mammalian sex chromosomes encode homologous X/Y gene pairs that were retained on the male Y and escape X chromosome inactivation (XCI) in females. Inferred to reflect X/Y-pair dosage sensitivity, monosomy X is a leading cause of miscarriage in humans with near full penetrance. This phenotype is shared with many other mammals but not the mouse, which offers sophisticated genetic tools to...

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Literature Corpus work
2c119654-80fb-56ab-b067-ec57507d963e
DOI
10.1101/2021.12.13.472325
Open publication

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Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placentaDOI 10.1101/2021.12.13.472325
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