Article

<i>In-vitro</i> cellular reprogramming to model gonad development and its disorders

2021-10-24

Abstract excerpt

During embryonic development, mutually antagonistic signaling cascades determine the fate of the bipotential gonad towards a testicular or ovarian identity. Errors in this process result in human Disorders of Sex Development (DSDs), where there is discordance between chromosomal, gonadal, and anatomical sex. The absence of an appropriate, accessible in-vitro system is a major obstacle in understanding mechanisms...

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Identifiers and source

Literature Corpus work: 8feef282-1a59-5171-943f-f04fc62bb362
DOI: 10.1101/2021.10.22.465384

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