Article

Isogenic hiPSC models of Turner syndrome development reveal shared roles of inactive X and Y in the human cranial neural crest network

2023-03-09

Abstract excerpt

<h4>SUMMARY</h4> Modeling the developmental etiology of viable human aneuploidy can be challenging in rodents due to syntenic boundaries, or primate-specific biology. In humans, monosomy-X (45,X) causes Turner syndrome (TS), altering craniofacial, skeletal, endocrine, and cardiovascular development, which in contrast remain unaffected in 39,X-mice. To learn how human monosomy-X may impact early embryonic developm...

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Literature Corpus work: c5a452e4-ea5a-5ea0-a996-a578f389aec9
DOI: 10.1101/2023.03.08.531747

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