Article

Latrophilins are essential for endothelial junctional fluid shear stress mechanotransduction

2020-02-04

Abstract excerpt

Endothelial cell (EC) responses to fluid shear stress (FSS) are crucial for vascular development, adult physiology and disease. PECAM1 is an important transducer but earlier events remain poorly understood. We therefore investigated heterotrimeric G proteins in FSS sensing. Knockdown (KD) in ECs of single Gα proteins had little effect but combined depletion of Gαi and Gαq/11 blocked all known PECAM1-dependent resp...

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Literature Corpus work: c334f6e2-cedc-591a-bd4c-890b33f5c17c
DOI: 10.1101/2020.02.03.932822

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