Article

Prucalopride ameliorates delayed gastrointestinal transit and social behaviour in a mouse model of 15q duplication syndrome

2025-03-10

Abstract excerpt

<h4>Introduction</h4> Chromosome 15q duplication syndrome (Dup15q) is a neurodevelopmental disorder linked to autism spectrum disorder (ASD), involving increased copies of the 15q11.2-q13 region. About 80% of individuals with Dup15q experience gastrointestinal (GI) dysfunction, including constipation. The duplicated region encodes GABA receptor A subunits, affecting GABAergic signalling, while reduced serotonin (...

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Literature Corpus work: 13153fc8-ac0d-5fea-bc02-c5ffcab66404
DOI: 10.1101/2025.03.03.640221

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